We study the tumour microenvironment in both acute myeloid leukaemia (AML) and multiple myeloma (MM). With increasing understanding of tumour pathogenesis, we have recognised the vital role the BM microenvironment plays in supporting tumour growth. We have investigated how interactions between tumour cells and the bone marrow microenvironment drive metabolic changes within the tumour cell. By improving our understanding of how tumour cells manipulate their microenvironment to promote tumour growth and survival, we hope to identify new targets that could be used in the treatment of AML and MM to improve the outcome for patients.
Using our knowledge of the bone marrow microenvironment in malignancy we now study the physiology of haematopoietic stem cells (HSC) in infection. We have investigated the metabolic changes in HSC in response to infection and the role of the bone marrow microenvironment in supporting these changes. We also study the role ageing and senescence in changing bone marrow function both in response to infection and in the malignant setting. An improved understanding of the bone marrow response to infection and the impact of ageing and senescence on its function will help to improve treatments for cancer and age-related diseases.